|
KMID : 1144820230290030152
|
|
대한의생명과학회지
2023 Volume.29 No. 3 p.152 ~ p.158
|
|
|
Analgesic Effect of Syneilesis aconitifolia Maxim. Extract on Animal Pain Model
|
|
Lee Gil-Hyun
|
|
|
Abstract
|
|
|
|
The aim of this study is to investigate the analgesic effects of Syneilesis aconitifolia Maxim. extract (SAM). We evaluated analgesic effects of SAM on animal pain model. Male SD rats were administered intra-orally with SAM according to prescribed dosage. During 7 days. After 7 days later, serum TNF-α, IL-1β, and IL-6 levels were measured by ELISA. In our experiment, administration of SAM decreased IL-1β, IL-6, TNF-α and PGE2 level in serum. Furthermore, it was confirmed that allodynia was relieved in evaluation of pain behavior. It was confirmed that administration of SAM reduces nociceptive pain by reducing nociceptive stimuli by acting as an anti-inflammatory drug.
|
|
|
KEYWORD
|
|
|
Syneilesis aconitifolia Maxim., Animal pain model, Nociceptive pain, TNF-α, IL-1β, IL-6
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|